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Heartworm Preventive Comparison Chart for Dogs and Cats Wendy Brooks, DVM, DABVP Revised: April 11, 2023 Additional Resources Confused about heartworm prevention options? These two charts compare current heartworm preventive products side by side to assist you in determining which is right for your situation. In the second chart, LD50 stands for lethal dose to 50 percent of a population. Typically lethal doses are expressed as oral (toxin taken by mouth) or by dermal (toxin placed on the skin). LD50s are usually determined with lab animal species such as rats, mice, and rabbits, but occasionally information is available for dogs. LD50s are expressed in milligrams of ingredient per kilogram of animal body weight (i.e. mg/kg) and provides a way to compare the toxicity of different substances. The higher the LD50, the less toxic a substance is. Some of the materials reviewed here are so safe that LD50 has not been determined and we can only say that it is greater than a certain amount tested. The highest numbers represent the safest numbers. Not all products listed here are available in every country. Always check with your veterinarian about the best options for your pet. For Heartworm Preventing Ingredient Other Ingredients for Control of Other Parasites Other Parasites Controlled Mode of Application Youngest Age to Start Using Heartgard Dogs Ivermectin None None oral 6 weeks Heartgard Plus, Dogs Ivermectin Pyrantel hookworms, roundworms oral 6 weeks Heartgard Cats Ivermectin None hookworms oral 6 weeks Interceptor, Dogs Milbemycin Oxime None hookworms, roundworms, whipworms oral 4 weeks Interceptor Plus Dogs Milbemycin Oxime Praziquantel hookworms, roundworms, whipworms, tapeworms oral 6 weeks (and at least 2 lbs) Sentinel, Dogs Milbemycin Oxime Lufenuron hookworms, roundworms, whipworms, sterilizes fleas oral 6 weeks (and at least 2 lbs) Revolution, Dogs Selamectin None For dogs: fleas, ticks, ear mites, sarcoptic mange mites topical 6 weeks Advantage Multi, Dogs Moxidectin Imidacloprid For dogs: fleas, hookworms, roundworms, whipworms topical 7 weeks Proheart 6, Dogs Moxidectin None hookworms injectable 6 months for Proheart 6, 12 months for Proheart 12 Trifexis Dogs Milbemycin Oxime Spinosad fleas, hookworms, roundworms, whipworms oral 8 weeks Coraxis Dogs Moxidectin None roundworms, hookworms, whipworms topical 7 weeks (and at least 3 lbs) Simparica Trio Dogs Moxidectin Sarolaner, pyrantel pamoate fleas, ticks, roundworms, hookworms oral 8 weeks (and at least 2.8 lbs) Bravecto Plus Cats Moxidectin Fluralaner (for fleas and ticks) ticks, fleas, hookworms, roundworms topcial 6 months NexGard Spectra Dogs Milbemycin Oxime Afoxolaner flea, tick, mites, heartworm, hookworm, roundworm, oral 8 weeks (and at least 4.4lbs) How Often Used Approved for Pregnancy and Lactation? Water-proof? Safe to Give to Heartworm Positive Animal? Manufacturer Website Heartgard for Dogs Monthly yes yes yes Heartgard 10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel Heartgard Plus, monthly yes yes yes Heartgard Plus 10 mg/kg in rats orally for ivermectin; Heartgard for Cats monthly yes yes yes Heartgard 10 mg/kg in rats orally Interceptor, monthly yes yes In most cases yes but if microfilariae numbers are high then no LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose Interceptor Plus monthly not tested for lactation, consult your vet regarding use in pregnancies yes In most cases yes but if microfilariae numbers are high then no LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose Sentinel, Sentinel Spectrum monthly yes yes In most cases yes but if microfilariae numbers are high then no LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose Revolution, monthly yes yes yes >1600 mg/kg in the rat orally Advantage Multi, monthly no no yes Moxidectin: 106 mg/kg orally; Proheart 6, every 6 months for Proheart 6, yes yes No, in fact, owner must agree to pre-treatment labwork including heartworm testing 263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg) Trifexis monthly Manufacturer cautions use, says to discuss with your veterinarian yes In most cases, yes but if microfilariae numbers are high then no Milbemycin Oxime: LD50 information unavailable Coraxis monthly no no yes BayerDVM 106 mg/kg orally Simparica Trio monthly no yes no 783 mg/kg for rats orally Bravecto Plus every 2 months no no manufacturer recommends use with caution Fluralaner: Dermal LD50: >2000mg/kg (rat) NexGard Spectra monthly not tested for pregnancy or lactation, consult your vet regarding use in pregnancies yes Not evaluated by manufacturer Afoxolaner: up to 1,000mg/kg orally in rats Feedback on this article
Published: January 01, 2001
Dogs or Cats
for Dogs
Iverhart Plus,
Iverhart Max,
Triheart Plus,
Pet Trust Plus
Pamoate
Iverhart Max also
has praziquantel
Iverhart Max also covers tapeworms
for Cats
MilbeGuard,
Milbehart
and Cats
for puppies
6 weeks
for kittens
Sentinel Spectrum
Sentinel Spectrum also has praziquantel
Sentinel Spectrum also covers tapeworms
Paradyne, Revolt
and Cats
For Cats: fleas, ear mites, hookworms, roundworms
for puppies
8 weeks
for kittens
Imoxi Topical
and Cats
For Cats: fleas, ear mites, hookworms, roundworms
for puppies
9 weeks
for kittens
Proheart 12
whipworms, flea tapeworms
Iverhart Plus,
Iverhart Max,
Triheart Plus,
Pet Trust Plus
Iverhart Plus
Iverhart Max
Triheart Plus
PetTrustPlus
>690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb
MilbeGuard,
Milbehart
Paradyne, Revolt
Imoxi Topical
Imidacloprid: 450 mg/kg in the rat orally
Proheart 12
every 12 months for Proheart 12
Spinosad: >3,000 mg/kg in rats; >2,000 mg/kg in rabbits (translates to over 30 times recommended dose)
Moxidectin: 106 mg/kg orally
Milbemycin oxime: range of 532mg/kg-946mg/kg, varied in mice and rats.
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